Recorded onsite at SLAS2023 in San Diego, California, podcast Editor Rob Howes speaks with Davide Gianni, Ph.D. (AstraZeneca) to learn more about Gianni's protocol paper, "A multi-parametric high throughput assay for detecting beta-cell proliferation in dispersed primary islets," published in Volume 28, Issue 2 of SLAS Discovery.
Here Davide describes the development of a 384-well plate-based multi-parametric imaging assay designed to capture ex vivo primary islet proliferation, a known pathology related to Diabetes. The development of this assay allows for the positive identification of compounds that can selectively enhance islet beta-cell proliferation and reverse this known disease phenotype.
For more information about SLAS Discovery, visit https://slas-discovery.org/